Gene information
Official symbol TNFSF4
Official full name TNF superfamily member 4
Gene type protein-coding gene
Chromosome1q25.1
Alias symbolOX-40L; gp34; CD252
Previous symbolTXGP1
Gene familyCD molecules; Tumor necrosis factor superfamily
Resources
Entrez Gene 7292
HGNC HGNC:11934
Ensembl ENSG00000117586
Vega OTTHUMG00000034838
UCSC uc001giw.4
GO terms: 75 records
GO Description Category LogP Number of genes Detail
GO:0000018 regulation of DNA recombination GO Biological Processes -2.30127410 6 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002695 negative regulation of leukocyte activation GO Biological Processes -9.84552767 31 More
GO:0002703 regulation of leukocyte mediated immunity GO Biological Processes -18.0432682 27 More
GO:0002718 regulation of cytokine production involved in immune response GO Biological Processes -15.9157324 18 More
GO:0002720 positive regulation of cytokine production involved in immune response GO Biological Processes -8.11676834 10 More
GO:0002724 regulation of T cell cytokine production GO Biological Processes -9.29772341 9 More
GO:0002726 positive regulation of T cell cytokine production GO Biological Processes -6.29956701 6 More
GO:0002821 positive regulation of adaptive immune response GO Biological Processes -12.1298033 16 More
GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -10.1498702 14 More
GO:0002825 regulation of T-helper 1 type immune response GO Biological Processes -5.99805120 6 More
GO:0002828 regulation of type 2 immune response GO Biological Processes -8.52846045 8 More
GO:0002830 positive regulation of type 2 immune response GO Biological Processes -7.53000143 6 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0009615 response to virus GO Biological Processes -11.2861143 47 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0022408 negative regulation of cell-cell adhesion GO Biological Processes -15.9068791 40 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032642 regulation of chemokine production GO Biological Processes -25.2850711 37 More
GO:0032649 regulation of interferon-gamma production GO Biological Processes -12.4733429 27 More
GO:0032653 regulation of interleukin-10 production GO Biological Processes -10.1959901 18 More
GO:0032673 regulation of interleukin-4 production GO Biological Processes -3.21772170 4 More
GO:0032675 regulation of interleukin-6 production GO Biological Processes -28.2553997 51 More
GO:0032689 negative regulation of interferon-gamma production GO Biological Processes -6.05054543 11 More
GO:0032729 positive regulation of interferon-gamma production GO Biological Processes -7.58110530 10 More
GO:0032753 positive regulation of interleukin-4 production GO Biological Processes -2.50427121 3 More
GO:0032755 positive regulation of interleukin-6 production GO Biological Processes -18.6559032 31 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation GO Biological Processes -5.90313372 12 More
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation GO Biological Processes -5.73056952 6 More
GO:0043433 negative regulation of DNA-binding transcription factor activity GO Biological Processes -10.6964949 32 More
GO:0045580 regulation of T cell differentiation GO Biological Processes -7.18541630 25 More
GO:0045581 negative regulation of T cell differentiation GO Biological Processes -3.22341771 8 More
GO:0045582 positive regulation of T cell differentiation GO Biological Processes -5.99210992 10 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045620 negative regulation of lymphocyte differentiation GO Biological Processes -5.62617381 12 More
GO:0045622 regulation of T-helper cell differentiation GO Biological Processes -5.35296451 10 More
GO:0045624 positive regulation of T-helper cell differentiation GO Biological Processes -3.92081595 4 More
GO:0045628 regulation of T-helper 2 cell differentiation GO Biological Processes -5.22169943 4 More
GO:0045630 positive regulation of T-helper 2 cell differentiation GO Biological Processes -6.17980212 4 More
GO:0046634 regulation of alpha-beta T cell activation GO Biological Processes -7.20313216 11 More
GO:0046635 positive regulation of alpha-beta T cell activation GO Biological Processes -5.84288222 8 More
GO:0046637 regulation of alpha-beta T cell differentiation GO Biological Processes -6.05306731 14 More
GO:0046638 positive regulation of alpha-beta T cell differentiation GO Biological Processes -5.69888611 7 More
GO:0046640 regulation of alpha-beta T cell proliferation GO Biological Processes -2.02099167 3 More
GO:0046641 positive regulation of alpha-beta T cell proliferation GO Biological Processes -2.61017926 3 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050777 negative regulation of immune response GO Biological Processes -11.1440698 32 More
GO:0050866 negative regulation of cell activation GO Biological Processes -13.9027363 39 More
GO:0050868 negative regulation of T cell activation GO Biological Processes -5.59075646 10 More
GO:0051052 regulation of DNA metabolic process GO Biological Processes -4.01973325 42 More
GO:0051090 regulation of DNA-binding transcription factor activity GO Biological Processes -25.8933515 78 More
GO:0051250 negative regulation of lymphocyte activation GO Biological Processes -7.76846228 25 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0097305 response to alcohol GO Biological Processes -17.4096682 46 More
GO:0097306 cellular response to alcohol GO Biological Processes -7.74675957 11 More
GO:1901654 response to ketone GO Biological Processes -10.4509771 32 More
GO:1901655 cellular response to ketone GO Biological Processes -4.22081481 14 More
GO:1902106 negative regulation of leukocyte differentiation GO Biological Processes -7.27922558 19 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903038 negative regulation of leukocyte cell-cell adhesion GO Biological Processes -10.2281373 27 More
GO:1903707 negative regulation of hemopoiesis GO Biological Processes -7.72888419 20 More
GO:2000514 regulation of CD4-positive, alpha-beta T cell activation GO Biological Processes -5.84288222 8 More
GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation GO Biological Processes -5.27280402 6 More
Drug-Gene interaction
view
Related drugs: 2 records
Drug name Interaction type Source PMID View
efizonerimod alfa TTD view
oxelumab inhibitor ChemblInteractions view
Related studies: 5 records
Molecular factor Omics type Application Objective MI type Reference
NC_000001.11:g.[173206693A>G;173208097C>T] genomics myocardial infarction[diagnosis] myocardial infarction Ria M et al. PLoS One. 2011
NM_003326.5:c.[203-288A>G;202+119A>G;154-5804T>C;154-8539T>C] genomics myocardial infarction[diagnosis] myocardial infarction Cheng J et al. Genet Mol Res. 2015
NC_000001.11:g.173208097C>T genomics myocardial infarction[diagnosis] myocardial infarction Ria M et al. PLoS One. 2011
NM_003326.5:c.154-5804T>C genomics myocardial infarction[diagnosis] myocardial infarction Cheng J et al. Genet Mol Res. 2015
NM_003326.5:c.153+331T>C genomics myocardial infarction[diagnosis] myocardial infarction Lu C et al. Biosci Rep. 2018
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